Hormones
Testosterone
Topical
Hormone health
Progesterone
Explore topical progesterone, formulation differences, and individualized hormone care.
Medical guidance
Clinical review required
3
Prices are indicative market-aligned medication pricing, not a quote. A licensed pharmacy confirms the final price for the exact formulation after a state-licensed clinician reviews your case.
Published market range: $39–$139 per month.
Availability and treatment are not guaranteed.
vidameds
Compounded medications are not FDA-approved.
Understanding Progesterone
Know the treatment.
Ask better questions.
The uploaded product depicts topical progesterone. Hormone care should be based on symptoms, medical history, and the proposed formulation; topical products should not be assumed equivalent to approved oral or vaginal progesterone.
How it works
Progesterone acts on hormone receptors, but absorption and effects depend on the delivery route and formulation. A compounded topical product may have variable absorption.
Safety & suitability
A clinician should review bleeding, relevant cancer history, other medicines, and pregnancy considerations. Topical progesterone should not be assumed to provide adequate endometrial protection when systemic estrogen is used in someone with a uterus.
Bring to your care conversation
- What evidence shows that the proposed route meets my clinical needs?
- What is the exact formulation, and which approved alternatives should I consider?
- What side effects, interactions, and follow-up should we discuss before a decision?
Research, in perspective
What the evidence says.
Topical absorption needs careful consideration.
A small 48-week study of a specific progesterone cream plus transdermal estradiol regimen did not demonstrate reliable endometrial protection. This was an uncontrolled, regimen-specific study, not a measurement of every cream's risk.
Evidence for approved oral or vaginal progesterone cannot be transferred to a compounded skin cream. When systemic estrogen is used in someone with a uterus, adequate endometrial protection is an important clinical question.
Read the sourcesEvidence at a glance
What has been studied
A small postmenopausal study of a specific topical regimen.
What remains unknown
Reliable protection and absorption for the pictured compounded product.
What this means for you
Evidence must match the ingredient, formulation, and condition. A biological mechanism is not a guaranteed clinical result.
01
Progesterone receptor activity
02
Absorption varies by route and formula
03
Endometrial protection cannot be assumed from a skin cream
Sources & further reading
- 01Transdermal estrogen with progesterone cream: Endometrial study (2005)
- 02FDA / NASEM: Evidence on compounded bioidentical hormone therapy
Research context is educational and does not confirm the safety, effectiveness, or availability of the pictured product.
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Treatment eligibility, medication availability, and shipping arrangements depend on clinical review and the prescribed medication. Customer support is not emergency care; call 911 for a medical emergency.
Beyond the medication
Find your balance. On your terms.
Changes in energy, mood, and wellbeing deserve a thoughtful conversation. Explore hormone care informed by symptoms, appropriate testing, and your individual needs.
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